Surface adsorption of fibronectin-derived peptide fragments: the influence of electrostatics and hydrophobicity for endothelial cells adhesion

Authors:

Satriano C. *1, Fragalà M.E 1, Forte G 2, Santoro A.M. 3, La Mendola D. 3, Kasemo B. 4

Abstract:

The adsorption on hydrophobic and hydrophilic silica-based surfaces of the integrin-binding PHSRN peptide and the single-residual-mutated analogues, PHSEN and PHSFN, is investigated by comparative QCM-D, XPS, SFG measurements and molecular dynamics calculations. Endothelial cell cultures on the peptide-functionalized materials highlight their tunable pro- or anti-angiogenic potential.

Year:

2012

Journal:

Soft Matter, 2012, 8, 53-56

Organization:

a Department of Chemical Sciences and INSTM, Catania University, viale Andrea Doria, 6, 95125, Catania, Italy. E-

b Department of Pharmaceutical Sciences, Catania University, viale Andrea Doria, 6, 95125, Catania, Italy

c Institute of Biostructures and Bioimages, CNR-Catania, viale Andrea Doria, 6, 95125, Catania, Italy

d Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden